Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). Sorry, this post was deleted by the person who originally posted it. The half-life really makes this unsuited for recreational use imo. And anything else you might like to add. Memantine is a prescription drug that is also known by the brand name Namenda. If you over shoot it, it's a very long time to endure it. You will be given a small dose when you first start treatment. Deprescribing ChEIs and memantine through shared decision making with individuals and their caregivers by: determining their treatment goals; discussing benefits and harms of continuing and ceasing medication, from the start of therapy and throughout; and engaging them in monitoring after discontinuation, while informing carers that the individual will continue to decline after discontinuation. Super Sour Ketamine is what I would describe the taste as. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. Common side effects … The high is quite non-intrusive though so it's really best used for a background high I think. I'm super happy I'm not the only one around here using it like this. It doesn't appear in any feeds, and anyone with a direct link to it will see a message like this one. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. It produces an amazing unique physical euphoria, even in low doses, it's very clear headed, and the visuals are somewhat unique, although I cannot compare it to dissociatives other than Ketamine, DXM & Nitrous. Don't re-dose thinking it wasn't a high enough dose, you'll regret the compounding effects of multiple doses. Memantine acts as a mild stimulant, raising heart rate and with a sense of weightlessness it feels encouraging to be physically active at low doses. 85mg Memantine Trip Report from January 2019 (edited, repost) Experience Report. Don't dismiss it based on the lack of information that exists on here and elsewhere currently on the internet. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. It is taken by mouth. 278 Memantine blocks the extensive activity of NMDA receptors but does not accumulate to interfere with normal synaptic transmission, and hence no disruption of normal physiological activity. I tried memantine a few times and enjoyed it enough, but itâs a weird one, isnât it? Preface. I light up a cigarette, like after most meals, and notice the slow whisps of smoke dancing around my hand, this is when I remembered about the Memantine, about 2 hours after taking the dose. I feel very clear-headed on memantine. (Yes, citric acid causes your urine to become more alkaline, I learnt the hard way) A single oral dose is highly recommended. Memantine is een geneesmiddel dat geregistreerd is voor de behandeling van patiënten met een matige tot ernstige vorm van de ziekte van Alzheimer.Het behandelt de oorzaak van de ziekte niet maar het laat toe dat patiënten misschien wat langer zelfstandig kunnen functioneren. Reddit; Wechat; To the Editor, We read with interest the papers by Brenner 1 and Cimolai 2 regarding the therapeutic potential of memantine for coronavirus disease 2019 (COVID‐19). Thanks! The Memantine market has witnessed growth from USD XX million to USD XX million from 2014 to 2019. With that being said, I don't think memantine would be an enjoyable experience for everyone. User Reviews for Memantine. Sweet write up, it sounds like an interesting drug worth experiencing. Additional information on Memantine can be found: https://psychonautwiki.org/wiki/Memantine, https://www.erowid.org/pharms/memantine/memantine.shtml, Edit: If you've found this post recently, I've made a follow up post, answering some of the frequently asked questions I was receiving after making this post HERE. YOU WILL BE BANNED FOR ASKING OR PROVIDING DRUG OR PARAPHERNALIA SOURCES, whether illegal or legal. 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. But if you like dissociatives like DXM/Ketamine, I think it's definitely worth trying. To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. Some gastro-intestinal disturbances could be possible however, due to D2 agonism, there's not much info on this. The physical euphoria is almost like a soft buzzing, underneath the skin, most noticably in the hands, toungue, scalp, and behind the legs. However, due to ketamine's difficultly to find, expense, and potential damage to the bladder, it isn't something I can regularly use. It was first developed in the 1960s for the treatment of diabetes. Upwards of 100mg and the dissociation becomes much more apparent, visuals will take form in the way of perceptual changes; depth perception alteration, visual acuity and colour enhancements are some of the most apparent effects. We promote harm reduction and fight against the drugs stigma. Ketamine: Much less sedating. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. Do you have any previous experience with dissociatives, and if so how do they compare? Although doses will vary from person to person, I believe most beginner users would do well with 50mg as a starting recreational dose. For those who want to use memantine for treating … Just remember that there is no 100% safe drug use. Not using is always safer. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. Store memantine at room temperature away from moisture and heat. If it isn't apparent guys, I have a lot of spare time. 2019 One meta-analysis showed that there was a significant improvement in cognitive function in AD patients who took memantine. Namenda (memantine): “My PCP put me on Namenda to supplement my Aricept for Alzheimer's Disease . The new dementia NICE guidelines published in June 2018 state that we should consider memantine for patients with moderate Alzheimer’s Disease and offer memantine for people with severe Alzheimer’s Disease, and if the person is already It has a pretty clear anxiolytic effect on me. The results have shown a significant difference in the behavior and attention deficit between the two groups treated with memantine and placebo during 6 weeks (p < 0.001). Make sure you follow the RULES. Pharms - Memantine (309), Sleep Deprivation (140) : General (1), First Times (2), Hangover / Days After (46), Multi-Day Experience (13), Various (28) COPYRIGHTS: All reports are copyright Erowid and you agree not to download or analyze the report data without … the headspace has much less "static" noise, even compared to being sober. In addition, alcohol, opiates, stimulants and other dissociatives should be avoided when on recreational doses of Memantine as unwanted side effects, such as increased heart rates, respiratory depression, nausea and in worst case death, may occur. Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. I can't explain much further, simply because I can't remember what happens when I do it. I'm not sure on what specific details your looking for but I can answer in more detail whatever questions you ask. Memantine is used for treatment of moderate-to-severe stage of AD. From experience, sublingual seems to have the fastest onset, and reasonable bioavailability, but the taste is rather unpleasant. The first week I was trialing it, I remember comparing the effects to that of Valium to my doctor and he seemed surprised by how well it was working. Score with placebo (median) Mean improvement in change score between memantine and placebo. It's worth noting I have never experienced nausea from Memantine, possibly due to the 5-HT3 antagonism. Less introspective. Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. There are over-the-counter medications available to acidify the urine too; for example, pills containing methionine, which is used to prevent bladder infections.' I have a few questions regarding its effects however. Press question mark to learn the rest of the keyboard shortcuts. Memantine is great. You can drink cranberry juice to acidify your urine throughout your trip to shorten it's duration, avoid citrus and other foods that basify your urine. In this study, we evaluated whether a combination of memantine with melatonin, administered for 32 days in drinking water, was more effective than either drug alone with respect to Aβ aggregates, neuroinflammation and cognition in the double transgenic APP/PS1 (5xFAD) mouse model of AD. Memantine seems less debilitating than that of Ketamine or DXM. When in doubt, DON'T. Whereas on DXM, it might be too hard to try to play a game. Treatment should only be continued if beneficial effects are seen. Memantine HCl is an antagonist of NMDAR.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of … A short intro to Memantine. Nice trip report. Low light settings let the visuals take hold much better and in complete darkness even 100mg may produce visuals on par with high Ketamine doses (for me high constitutes 200mg+), in a respective setting. I’d recommend slowly exploring higher doses, some of my heroic doses on Memantine have given me experiences I haven’t had on any other drug, and I’ve IM’d 300mg+ ketamine and taken doses as high as 125mg DCK, (on separate occasions) and they still haven’t touched the headspace I’ve reached on Memantine. Although the half life of Memantine in your body is around 80 hours, the subjective effects are somewhere closer between 12-24 hours, and can be reduced with the acidification of your urine, increasing it's excretion rate. Seeing as Erowid has limited information on Memantine this guide aims to add another resource out there. Then memantine is pulled into the channel to its binding site. I had structures I could interact with in the 3D world, put my arm behind and have my vision of my arm disappear but still being fully aware of the room I was in. Your doctor will need to check your progress while you are using memantine. How often do you use Memantine for depression? Euphoria is more and more present, but loss of fine and gross motor control becomes more apparent. It's heavily memory impairing for a few minutes, and fairly confusing at high doses. It still needs a little tidying up which i will get to over the next couple of days but i just wanted to say thank you. 3 McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J. Memantine as a treatment for dementia, Dementia and Cognitive Improvement Group. Press question mark to learn the rest of the keyboard shortcuts. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. I don't think it's for everyone, but it certainly has enough merit for those who like dissociatives to try. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. Both the research  and anecdotal reports  recount as much. A sub for discussing all uses of Memantine, from therapeutic to recreational. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Although there is moderate-certainty evidence that fewer people taking memantine experience agitation as an adverse event: RR 0.81 (95% CI 0.66 to 0.99) (25 fewer people per 1000, 95% CI 1 to 44 fewer), there is also moderate-certainty evidence, from three additional studies, suggesting that memantine is not beneficial as a treatment for agitation (e.g. And personally I enjoy it a lot. That being said, Memantine is a beautiful drug. Nice report. Is it possible to hole on? Ive had minimal unwanted physical side effects. ... T+03:00 Texted my friend for a bit, browsed Reddit, watched YouTube. Tobacco (most likely the nicotine, but I haven't ingested pure nicotine) also changes the subjective experience of Memantine, although only briefly. Press J to jump to the feed. Hey guys, some of you may recognise me as that guy who goes on and on about Memantine's recreational value whenever given the chance, but up until now I didn't really have a way to explain how one might approach Memantine if they were interested in it's recreational potential. Thanks again dude. I'd figured they would've found cough medicines that work just as well w/o being psychoactive during the War on Drugs but nah lol. Duration is manageable with correct dose amount and timing. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Memantine also is a Dopamine D2 agonist, a non-competitive Serotonin 5-HT3 antagonist, a non-competitive nAChRs antagonist with similar potencies to NMDA antagonism and the Sigma σ1 receptor with potentially negligible activity. OK just ingested 30 mg, we'll see, I don't want a full blown recreational high but I guess 30mg is good because many drugs just get my anxiety worse. When it is working I can think clearly. Could you describe to me in as much detail as possible how it feels in comparison to traditional dissociatives such as ketamine, mxe and dxm? The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. It's clean feeling, compared to DXM. I've never seen a new user format an article so legitimiately in accordance with the rest of the site. Furthermore, memantine caused short-term worsening of neurologic symptoms in MS, thereby exacerbating the cognitive deficits [ 41 ]. I was blown away the first time I tried Memantine with weed, it is comparable to DXM with and without weed. You can take memantine either before or after meals. As many comparisons to other common compounds as possible would be extremely useful for fleshing out the subjective effects section. I may be an outlier with medical significance but if there's even one other person who finds it as beneficial as I do then I'm more than happy to share whatever information I can on Memantine. It feels almost like you can will yourself in and out of consciousness at that dose. Also known as: Namenda, Namenda XR Memantine has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. However, the drug does not cure Alzheimer’s. Memantine helps to ease the symptoms of dementia in Alzheimer's disease. From my personal experience, however, there is little chance of mania or anxiety even in high doses especially in comparison to DXM, and throughout the entire trip you will have a sense of contentment unwavering. This is a risk reduction resource. Results were inconclusive because of studies with poor levels of … That way, memantine is eliminated 7-10 times faster. Dosing Memantine is simple, but requires some planning and forethought. 279, 280 Via inhibition of NMDA receptors, memantine prevents the mitochondrial swelling, increases oxidative stress, and decreases … However my memory lapses happen every 2 weeks or so and only for a short period. Memantine for dementia – what, why, who and when? Functional enough to play games like Overwatch and keep up with it without any struggle. One interesting memantine side effect includes higher libido. The biggest turn off I see people have with recreational use of Memantine is it's duration, and while not overly exaggerated it is manageable. This will … Population: mild Alzheimer's disease Intervention: memantine 20 mg Comparison: placebo . Seems to help my short term memory. I can't compare it to MXE, and it's been a few months since I last had ketamine but I'll do the best I can to explain. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. I could see some thereputic use in this because of it's functionality and long half life. Please comment back on what your experience was like at that dose though. Psychonautwiki founder here, you did an amazing job on the mementine article dude. With the CAGR of X.X%, this market is estimated to reach USD XX million in 2026. Memantine Dosage. Memantine, 3-MEO-PCE, LSD, 4-AcO-MiPT, 4-HO-MET, 2C-C, Clonazepam & Aripiprazole: Adventures in NMDA Receptor Antagonism: viscosity: Memantine & DXM: Just the Kick in the Teeth I Was Looking For: 180OnTheDVP: Memantine & Nitrous Oxide: Beyond Tollerance Reduction: Clyde T. The visuals and euphoria become much more intense and interesting after weed is smoked. The review covers memantine studies in postherpetic neuralgia, diabetic pain, postoperative pain, complex regional pain syndrome, chronic phantom limb pain, opioid‐refractory pain and fibromyalgia. Cheers man, I'll put it to good use. I have used ketamine in the past with the intention of helping depression and it was very pleasant at the time. A recent meta-analysis found substantial benefits of memantine in treating obsessive-compulsive disorder.