Vanessa Bouskill Colleen Jones Down Hematology/Oncology Clinic Tel. Always stay in touch with your treatment centre. London, Ontario  N6A 5W9 One uncle had had abnormal bleeding after a tooth extraction, but … In severe factor XIII deficiency, life threatening bleeding can occur, particularly intracranial bleeding. Clinic directors Always keep in contact with your hemophilia treatment centre. Moreover, after the hormones drop again, resulting in a reduction in coagulation factor VIII and von Willebrand factor in the period after delivery, women with a factor XI deficiency are at risk of abnormal bleeding. Nicole Graham As the name suggests, a hemophilia comprehensive care team is a team of specialists that provides most of the medical services required by a child or adult with an inherited bleeding disorder. Robbins observed that an unknown factor in plasma plays a role in the formation of an insoluble fibrin clot. Nurse coordinators They may recommend scheduling the extraction to coincide with the preventive dose of factor XIII concentrate, or, if necessary, treatment with factor XIII concentrate before the visit. Like other hemophiliacs, they have abnormal bleeding due to a lack of coagulation factors. If you are planning a trip, let your treatment centre know. Tel. Fax: 204-787-1743, Physiotherapists Preventive treatment means regular infusions of factor XIII, even if there is no sign of bleeding. : 519-685-8500 ext. : 519-685-8500 ext. The half-life of factor XIII is 9 to 12 days, whereas factor VIII half-life is about 12 hours and factor IX half-life is about 18 hours. The most common symptoms of factor XIII deficiency are: The following symptoms are less common. 300 Prince Philip Drive Fax: 519-685-8543, Physiotherapist Halifax, Nova Scotia  B3K 6R8 Dr. Irwin Walker Box 5010 Megan Chaigneau London Health Sciences Centre Tel. Natalie Benson Emergencies: 1-888-475-9922 Tel. Fax: 416-864-5310, Sudbury and North-Eastern Ontario Hemophilia Program The amount necessary to treat or prevent bleeding is diluted in less than 20 millilitres of sterile water. Ideally, the dose of factor XIII prescribed is rounded off so that the entire contents of the vial are administered. : 506-857-5467  Toll-free: 1-866-903-4642 London, Ontario  N6A 5W9, Clinic directors Factor XIII deficiency is an inherited blood clotting disorder that affects females as well as males. Fax: 807-684-5835, Bleeding Disorders Program Pager: 519-685-8500 ext. T: 403-955-7311, T: 403-955-7211 (after hours) Halifax, Nova Scotia  B3H 2E1 : 418-649-5751 On the other hand, factor XI concentrates are known to pose a risk of promoting development of intra-vascular clots, which, though rarely, can endanger a patient’s life. Tel. If a bleed occurs, the person has access to quick and efficient treatment without having to go to a health care facility. Dr. Margaret Warner The majority of pregnancies in women with severe factor XIII deficiency end in miscarriage (spontaneous abortion), unless the patient receives factor XIII concentrate regularly during pregnancy. CH246 – 840 Sherbrook Street 501 Smyth Road, Box 248 Victory 1-3-224A Dr. Jayson Stoffman Never take aspirin. Pediatric Social Work Office Children’s Treatment Centre Camila Gundel Factor XIII deficiency is a very rare disease. 5334 Since 2012, recombinant factor XIII concentrate has been available in Canada. : 705-523-7337 ext. Dr. Stéphanie Cloutier, Nurse coordinator Health Sciences North Heidi Schmidt, MSW, RSW Alberta Children’s Hospital, Clinic director A variety of treatment and prevention options are available for bleeding, though they must be chosen with care. Stacey Cave This test does not measure the exact quantity of factor XIII, since even a very small amount (about 5% of normal) is enough to stabilize a clot in a qualitative test. Dr. Paul Moorehead Fax: 416-864-5310, Physiotherapists Winnipeg, Manitoba  R3A 1R8 Fax: 514-345-7749 Fax: 902-473-3398, Social worker  Tammy Betts Nurse coordinators Clinic directors 810 Sherbrook Street, MS107 First, when a blood vessel ruptures, it contracts as a reflex, which reduces the amount of blood loss. 2182 Nicole Zuefle Julie Cormier Claude Meilleur Fax: 902-470-7211, Inherited Bleeding Disorder Clinic In the American population overall, one person in 100,000 is diagnosed with factor XI deficiency, regardless of degree of severity. Patty Phrakonkham-Ali The A subunit is produced in bone marrow and the B sub-unit is produced in the liver. Umbilical and intracranial bleeds are much more frequent in people with factor XIII deficiency than in people with hemophilia A (factor VIII deficiency) or hemophilia B (factor IX deficiency). Nurse coordinator Patty Phrakonkham-Ali Tel: 519-685-8700 ext. Hemophilia associations are a good source of public information about programs for women with bleeding disorders. The result is that there is almost no abnormal bleeding once factor XIII concentrate is administered in adequate doses at suitable intervals. 1967 Riverside Drive, Box 28 Tel. Blake Richison, (backup) The first patients who were diagnosed with this disease were treated effectively with fresh frozen plasma. Dr. Kelsey Brose –  medical director, hematologist This page contains the Peer review requests that are older than one month, have received no response in the last two weeks, are not signed, have become featured article or featured list candidates, or did not follow the "How to use this page" principles in some way. 1001 Décarie Blvd Dr. Michelle Sholzberg Pager: 902-473-2220 # 2226 Tel. Heidi Schmidt, MSW, RSW Saint John, New Brunswick  E2L 4L2, Clinic directors 800 Commissioners Road East Physiotherapy Department The immune system does not recognize the new foreign protein, which is not produced by the body. DDAVP : 416-864-6060 ext. Factor XIII is a protein made up of two parts called subunits. Follow a regular program of physical activities suited to the individual’s preferences and capabilities, and adapted to individual circumstances. Cindy Milne Wren The product is highly concentrated. These are the parts of the body where clots dissolve quickly. Tel. Tel. Jennifer King Physiotherapy Department The half-life is the amount of time it takes for half the infused factor XIII to be cleared from the bloodstream. It is recommended that people who bleed mainly from the nose learn the subcutaneous injection technique. : 204-787-2641 Angela Ruzycki  A scheme where web server serves a default file on per-subdirectory basis has been supported as early as NCSA HTTPd 0.3beta (22 April 1993), which defaults to serve index.html file in the directory. : 902-470-8167 Kathleen Mead (played by Rebecca Haines) is a fictional character from the original Playing With Time television series, Degrassi Junior High.She was introduced as a secondary character who disapproved of school president Stephanie Kaye (played by Nicole Stoffman) and her provocative wardrobe but eventually went on to have a much greater role in the series. 865 Regent Street S., 4th floor Today, the risk of infection. Tel: 709-777-4374 (Coleen) A person with severe factor XIII deficiency should learn how to self-infuse factor XIII concentrate at home. Nurse coordinator Tel: 514-345-2360 (pager) It can be used alone or in conjunction with another drug, such as DDAVP, which helps increase its effectiveness. Nurse coordinator PO Box 9700 Dr. Elizabeth Zed Sudbury, Ontario  P3E 5J1 I'll guess I'll spoil things a bit and say that Nicole Stoffman, the actress who plays Steph, only sticks around for the first two seasons. Physiotherapy Department Christine Beaulieu : 514-345-4931 ext. Dr. Lauren Bolster Tel. Sudbury, Ontario  P3E 3Y9, Nurse coordinator Dr. Kelsey Brose –  medical director, hematologist McKenzie Quevillon Missing a tooth or several teeth is common. Winnipeg, Manitoba  R3A 1R8 Plasma is a blood derivative, a yellowish liquid that is rich in coagulation factors. Tel. Nurse coordinators Fax: 519-685-8543, Physiotherapist 71 Saint John, New Brunswick  E2L 4L2 These programs pool the expertise of several care teams, including gynecology and hematology specialists, in order to address the very special needs of women. The availability of plasma-derived factor XIII concentrate in different formats currently offers a clear economic advantage over recombinant factor XIII concentrate because the Pager: 905-521-5030 page 4444 (Kay)  /  page 4445 (Rebecca) Toronto, Ontario   M5G 1X8, Clinic directors Burrard Building, Room 491A, Clinic directors Dr. Alfonso Iorio, Nurse coordinators However, the type and frequency of bleeding in factor XI deficiency differ significantly from other types of hemophilia, as does treatment. Fax: 819-564-5434 (hematology), Physiotherapist This scheme has been then adopted by CERN HTTPd since at least 2.17beta (5 April 1994), which its default supports Welcome.html and welcome.html in addition to the NCSA-originated index.html. Dr. Christine A. Sabapathy 76 Stuart Street Dr. Paula James Fax: 519-685-8817, Stefan Branov It is not well known, even among health professionals. Stephanie Daigle : 807-684-7200 As a result, it is very difficult to predict the severity and frequency of bleeding simply on the basis of the percentage of factor XI in the blood. Fax: 403-944-3220, Social worker It removes the inconvenience of having to go to a health care facility every month. Halifax, Nova Scotia  B3K 6R8 : 416-864-5129 Quebec, Quebec  G1J 1Z4, Clinic directors 980 Oliver Road : 514-345-4931 ext. Lisa Thibeault Janice Spencer In order to prevent bleeding episodes in newborns at risk of being factor XI deficient, appropriate instructions are entered in the medical file so as to avoid potentially traumatic medical P.O. Wu Victoria Hospital, Room B1-301 The different preventive and treatment options available to people with factor XI deficiency all have their own advantages and disadvantages. A coagulogram is then done on a blood sample from the patient to measure the rate of clot formation. : 514-345-4607 Fax: 613-738-4839, Social workers : 418-649-5624 Queen Elizabeth II Health Sciences Centre 6999 It is then infused into a vein over a few minutes. : 418-649-5624 : 1-888-475-9922 (emergency) 3175 chemin de la Côte-Sainte-Catherine Josie Pilon Physiotherapy Department Physiotherapy Department Recombinant factor XIII is available in vials of 2,500 units. Room J4294 London Health Sciences Centre This is because the half life of factor XIII is about 10 days, and half the factor XIII is gone. 7055 Hematology/Oncology Clinic Dr. Leonard Minuk, Nurses Gail Bellussi Fax: 613-548-2435, Physiotherapist Tel. Dr. Leonardo Brandao, Nurse coordinators Whether the level of clotting factor deficiency the clotting factors formally recommended the designation of XIII! Perri Tel: 418-641-3479, Physiotherapists JoAnn Nilson Andrea Willenborg Tel which reduces the necessary. 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